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European network for biological deuteration for neutron scattering and nmr

European network for biological deuteration for neutron scattering and nmr

Objective

The D-LAB program aims to develop, produce and evaluate systems and protocols for the D/2H-labelling of biological macromolecules that will extend and enhance their structural and dynamical analysis at neutron scattering and NMR LSF throughout Europe. Specific objectives of D-LAB are to:
- Exploit developments at the central Deuteration Laboratory in Grenoble to enable more efficient production of specifically H/D-labelled cells, proteins, nucleic acids and other bio-molecules;
- Develop more efficient methods to produce deuterium labelled biological macromolecules that will benefit the European biological community;
- Evaluate and exploit these methods and reagents in improvement of downstream technology, including data collection and interpretation for neutron scattering and NMR;
- Train young scientists in these techniques. The tools and facilities produced will allow for higher throughput of experiments than are currently performed and will provide new, more sophisticated approaches to the solution of complex biological problems. The list of deliverables is considerable and includes new protocols and techniques for the production of H/D-labelled biological macromolecules and improved methods for analysis.

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Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Address

Jules Horowitz 6
38042 Grenoble

France

Administrative Contact

Stefan BACKMANN (Mr.)

Participants (4)

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COMMISSARIAT A L'ENERGIE ATOMIQUE

France

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

INSTITUT MAX VON LAUE - PAUL LANGEVIN

France

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Project information

Grant agreement ID: HPRI-CT-2001-50035

  • Start date

    1 November 2001

  • End date

    31 October 2004

Funded under:

FP5-HUMAN POTENTIAL

  • Overall budget:

    € 1 244 281

  • EU contribution

    € 999 000

Coordinated by:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

France