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Development of new strategies for treatment of amoebiasis, the parasitic disease caused by entamoeba histolytica

Project information

Grant agreement ID: ICA4-CT-2001-10073

  • Start date

    1 November 2001

  • End date

    30 April 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 995 355

  • EU contribution

    € 995 355

Coordinated by:

INSTITUT PASTEUR

France

Objective

Our remain rationale is that surface receptor-based research could have clinical application to control infectious diseases. The aim is to provide new target molecules for better diagnosis, vaccine and prophylaxis. The disease of interest is amoebiasis caused by Entamoeba histolytica, a parasite that represents a major public health problem in Latin America. Pathogenesis involves colonization and invasion of the human intestine and requires the activity of amoebic receptors like the Eh112 complex involved in phagocytosis of cells. We aim to provide targets for therapy and give rational alternatives for control of amoebiasis by a multidisciplinary approach extending from cell and molecular biology to immunology and epidemiological analysis. Key aspect are: parasite targets on human cells, phagocytosis by activation of the cytoskeleton, seroprevalence of Eh112 in endemic areas and assessment of the immune response.

Coordinator

INSTITUT PASTEUR

Address

Rue Du Docteur Roux 25
75724 Paris

France

Participants (4)

CUBAN CENTER FOR NEUROSCIENCE - NATIONAL CENTER FOR SCIENTIFIC RESEARCH

Cuba

INSTITUTO POLITECNICO NACIONAL

Mexico

INSTITUTO POLITECNICO NACIONAL

Mexico

UNIVERSITY OF BIRMINGHAM

United Kingdom

Project information

Grant agreement ID: ICA4-CT-2001-10073

  • Start date

    1 November 2001

  • End date

    30 April 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 995 355

  • EU contribution

    € 995 355

Coordinated by:

INSTITUT PASTEUR

France