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Diagnostic and epidemiological markers for tracking of endemic and resurgent european leishmaniasis

Project information

Grant agreement ID: QLK2-CT-2001-01810

  • Start date

    1 September 2001

  • End date

    30 November 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 514 210

  • EU contribution

    € 1 514 210

Coordinated by:

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

United Kingdom

Objective

Visceral leishmaniasis is one of the most important vector-borne zoonosis in Southern Europe and lacks reliable, rapid, simple and sensitive typing methods. The current reference typing method, allozyme electrophoresis, is demanding and has low-resolution power for genetic diversity and species taxonomy. We propose to develop new alternative molecular typing methods, based on clade-specific markers determined through DNA-based phylogenetic reconstructions. Phylogenies will be built from DNA sequences of genomic loci exhibiting a range of genetic variation from conserved to highly variable (microsatellites), and will be compared with allozyme-based phylogenies. Molecular typing procedures will be designed to fill the above-mentioned typing requirements. Applicability of the new markers will be evaluated for clinical typing of endemic and imported human and canine infections and for pilot studies of sympatric and allopatric populations, therefore addressing fundamental epidemiological and clinical questions. An electronic database for Leishmania typing data and strain information will be generated, and will be available through the Internet.

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

Address

Keppel Street
London

United Kingdom

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

HELLENIC PASTEUR INSTITUTE

Greece

HUMBOLDT-UNIVERSITAET BERLIN

Germany

INSTITUTE OF HEALTH CARLOS III

Spain

INSTITUTE OF PARASITOLOGY - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD

Belgium

UNIVERSIDADE NOVA DE LISBOA

Portugal

UNIVERSITE DE MONTPELLIER 1

France

UNIVERSITY OF CRETE

Greece

Project information

Grant agreement ID: QLK2-CT-2001-01810

  • Start date

    1 September 2001

  • End date

    30 November 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 514 210

  • EU contribution

    € 1 514 210

Coordinated by:

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

United Kingdom