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Early malnutrition and programming of adult degenerative diseases: experimental, epidemiological and preventive studies

Objective

Foetal and neonatal improper nutrition has been suggested to be associated with a high risk of developing obesity, diabetes, and cardio-vascular diseases by altering the early programming. A first aim is to analyse the early molecular and cellular events induced by imbalanced nutrition and their late consequences in organs targeted by these degenerative diseases: endocrine pancreas, liver,adipocytes and vasculature. The relevance will be evaluated in human epidemiological studies. The second aim is to determine key nutrients responsible for the defects, to propose prevention. The proposal combines the expertise of European centres, 4 of them being laboratories leader in dietary manipulated rodents and one being an epidemiological centre where dietary intake is of main concern.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE CATHOLIQUE DE LOUVAIN
Address
Place Croix Du Sud 5
1348 Louvain-la-neuve
Belgium

Participants (4)

DANISH EPIDEMIOLOGY SCIENCE CENTRE
Denmark
Address
10,Artillerivej 5, Building 206
2300 Koepenhagen
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
48 Boulevard Serurier
75019 Paris
ROWETT RESEARCH INSTITUTE
United Kingdom
Address
Greenburn Road
AB21 9SB Aberdeen
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Hills Road Addenbrooke's Hospital
CB2 2QR Cambridge