Foetal and neonatal improper nutrition has been suggested to be associated with a high risk of developing obesity, diabetes, and cardio-vascular diseases by altering the early programming. A first aim is to analyse the early molecular and cellular events induced by imbalanced nutrition and their late consequences in organs targeted by these degenerative diseases: endocrine pancreas, liver,adipocytes and vasculature. The relevance will be evaluated in human epidemiological studies. The second aim is to determine key nutrients responsible for the defects, to propose prevention. The proposal combines the expertise of European centres, 4 of them being laboratories leader in dietary manipulated rodents and one being an epidemiological centre where dietary intake is of main concern.
Funding SchemeCSC - Cost-sharing contracts
AB21 9SB Aberdeen
CB2 2QR Cambridge