Objective Foetal and neonatal improper nutrition has been suggested to be associated with a high risk of developing obesity, diabetes, and cardio-vascular diseases by altering the early programming. A first aim is to analyse the early molecular and cellular events induced by imbalanced nutrition and their late consequences in organs targeted by these degenerative diseases: endocrine pancreas, liver,adipocytes and vasculature. The relevance will be evaluated in human epidemiological studies. The second aim is to determine key nutrients responsible for the defects, to propose prevention. The proposal combines the expertise of European centres, 4 of them being laboratories leader in dietary manipulated rodents and one being an epidemiological centre where dietary intake is of main concern. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health scienceshealth sciencesnutritionobesity Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-1. - Key action Food, Nutrition and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITE CATHOLIQUE DE LOUVAIN EU contribution No data Address Place Croix du Sud 5 1348 LOUVAIN-LA-NEUVE Belgium See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANISH EPIDEMIOLOGY SCIENCE CENTRE Denmark EU contribution No data Address 10,Artillerivej 5, Building 206 2300 KOEPENHAGEN See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address 48 Boulevard Serurier 75019 PARIS See on map Total cost No data ROWETT RESEARCH INSTITUTE United Kingdom EU contribution No data Address Greenburn Road AB21 9SB ABERDEEN See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address Hills Road Addenbrooke's Hospital CB2 2QR Cambridge See on map Total cost No data