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Identification of efficacious delivery systems for recombinant and nucleic acid construct vaccines (EFFICACIOUS DELIVERY)

Project information

Grant agreement ID: QLK2-CT-2001-01346

  • Start date

    1 September 2001

  • End date

    28 February 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 579 930

  • EU contribution

    € 1 175 204

Coordinated by:

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH

Germany

Objective

Classical swine fever virus (CSFV) is a well-suited model for the evaluation of protective immunity in swine induced by virus subunits. Novel vaccines, which are investigated in this project, can be divided into two groups, 1. Viral subunit antigens generated in vitro and 2. DNA- or RNA-based delivery systems and a Para poxvirus-based expression system, producing the relevant antigens in vivo. In addition the modification of such vaccines with potent immuno-modulatorymolecules and loading of dendrite cells (DC) will be tested for improving stimulatory-stimulatory effects in swine. Since only highly efficacious vaccines are responsible for a rapid onset of protection in naive animal populations this study will focus on the immune response after primary vaccination. The results of the study will provide sufficient information to be able to identify efficient vaccine-types against CSFV as well as other emerging diseases.

Coordinator

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH

Address

Paul Ehrlichstr. 28
72076 Tuebingen

Germany

Participants (6)

AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS

France

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW

Belgium

INSTITUTE OF VIROLOGY AND IMMUNOPROPHYLAXIS

Switzerland

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

THE UNIVERSITY OF TUEBINGEN

Germany

UNIVERSITY OF VETERINARY MEDICINE VIENNA

Austria

Project information

Grant agreement ID: QLK2-CT-2001-01346

  • Start date

    1 September 2001

  • End date

    28 February 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 579 930

  • EU contribution

    € 1 175 204

Coordinated by:

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH

Germany