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Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae rna polymerase (VIRRNAPOLDRUGTARGET)

Objective

The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerise (Drip) of these viruses, the replicas, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy. Seven partners will perform a structure-function analysis of the replicas, its viral, and possibly cellular, cofactors, and of its unique template, the nucleocapsid, in the presence or absence of antiviral drugs. To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a "poly-erase toolbox' which will enable a panel of 5 European SME to model the replicas and its template from any related viruses and design new antiviral drugs & vaccine.

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Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1

Address

Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne

France

Administrative Contact

Domition DEBOUZIE (Prof.)

Participants (9)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

INSTITUTE OF HEALTH CARLOS III

Spain

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

MEDICAL RESEARCH COUNCIL

United Kingdom

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

UNIVERSITY OF GENEVA

Switzerland

UNIVERSITÉ DE PROVENCE, AIX-MARSEILLE

France

Project information

Grant agreement ID: QLK2-CT-2001-01225

  • Start date

    1 September 2001

  • End date

    30 November 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 239 255

  • EU contribution

    € 1 307 052

Coordinated by:

UNIVERSITE CLAUDE BERNARD LYON 1

France