CORDIS
EU research results

CORDIS

English EN

Use of simple embryos to search for unknown genes controlling cell proliferation and death

Project information

Grant agreement ID: QLK3-CT-2001-01890

  • Start date

    1 October 2001

  • End date

    31 March 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 3 201 800

  • EU contribution

    € 1 888 198

Coordinated by:

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Objective

Tumourigenesis may result from a de-regulation of genes that normally control embryonic development. We propose to use simple ascidians and fish embryos as tools to analyse the genetic diversity underlying cell proliferation and death. These embryos have a simple genome, and genes similar to human ones. We will perform a systematic screen for genes expressed in areas of cell proliferation and death. Putative roles for the new gene families will be inferred from expression pattern studies (acquired in a database), and then tested in embryos and cancer cells. In particular, we plan to use a novel and extremely potent generation of antisepses oligonucleotides, with potential therapeutic outcomes. The major goal of this project is therefore, by taking advantage of the use of simple chordate entry’s, to identify new types of regulators of human cell proliferation and death, which are good candidates to design anti-cancer drugs.

Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

Address

Cnrs - Avenue De La Terrasse
91198 Gif Sur Yvette

France

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

ONCODESIGN S.A.

France

STAZIONE ZOOLOGICA ANTON DOHRN

Italy

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

Project information

Grant agreement ID: QLK3-CT-2001-01890

  • Start date

    1 October 2001

  • End date

    31 March 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 3 201 800

  • EU contribution

    € 1 888 198

Coordinated by:

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France