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Development and clinical study of a bioartificial liver based on reversibly immortalised human hepatocytes

Project information

Grant agreement ID: QLK3-CT-2001-01889

  • Start date

    1 September 2001

  • End date

    31 August 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 469 814

  • EU contribution

    € 2 226 380

Coordinated by:

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

Objective

Mortality of acute liver failure is high, an alternative to transplantation is needed and hepatic assist systems taking over the complex liver function are still in the experimental phase. Two promising European bio artificial liver (BAL) systems have been tested with porcine cells. Large clinical use of Balls (like renal dialysis for renal patients) becomes possible when safe, functional cells can be cultivated in large numbers. We aim to develop an effective safe BAL with reversibly immortalised human hepatocytes. This will be achieved by development of reversibly immortalised cell lines, in vitro safety and functionality tests of the cell lines and 1 existing cell line, testing favourable cell lines in the Balls, cell preservation studies, bioreactor improve, in vivo studies of one or both Balls or a hybrid BAL with the most favourable cell line, phase I clinical trials, founding an SME to cultivate the cells and to load Balls with them.

Coordinator

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Address

Meibergdreef 9, Academisch Medisch Centrum
1100 Dd Amsterdam

Netherlands

Participants (5)

AZIENDA OSPEDALIERA A. CARDARELLI

Italy

HUMBOLDT-UNIVERSITAET BERLIN

Germany

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITE DE RENNES 1

France

University of Edinburgh

United Kingdom

Project information

Grant agreement ID: QLK3-CT-2001-01889

  • Start date

    1 September 2001

  • End date

    31 August 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 469 814

  • EU contribution

    € 2 226 380

Coordinated by:

ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands