Objective Disturbances of body water balance severely affect the quality of life and can lead to life-threatening conditions. Aqua Orin (AQP) water channels play central roles in human water balance and are novel targets for pharmacological intervention. To screen for blockers (aqua plugs) of Asps, mammalian and yeast cell systems will be established. Inhibitors of aqua Orin function will be identified in compound libraries and rationally designed. The activity, specificity and toxicity profile of these aqua plugs will be determined in optimised cell- and integrated, systems. The atomic structures of Asps and AQP-aqua plug complexes will be elucidated and used to design optimised aqua Orin inhibitors. Studies will be performed to further determine the role of Asps in organ water balance in health and disease to identify additional conditions where Asps are targets for pharmaceutical application of aqua plugs. Identified aqua plugs with promising profiles will serve as lead structures for the development and exploitation of specific aqua Orin inhibitors in novel skin care products and diuretics. Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator STICHTING KATHOLIEKE UNIVERSITEIT EU contribution No data Address Adelbertusplein 1 6500 HB NIJMEGEN Netherlands See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all BEIERSDORF A.G. Germany EU contribution No data Address Unnastrasse 48 20253 HAMBURG See on map Total cost No data GOETEBORG UNIVERSITY Sweden EU contribution No data Address Lundberg Laboratory 405 30 Göteborg See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address 11,Am Fassberg 11 37077 GOETTINGEN See on map Total cost No data UNIVERSITAET BASEL Switzerland EU contribution No data Address Klingelbergstrasse 70 4056 BASEL See on map Total cost No data UNIVERSITY OF AARHUS Denmark EU contribution No data Address 1,Wilhelm Meyers Allee, Building 234 234 8000 AARHUS C See on map Total cost No data UNIVERSITY OF EDINBURGH United Kingdom EU contribution No data Address West Mains Road, Kings Buildings EH 3JJ EDINBURGH See on map Total cost No data