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Phase-i and ii trials of the malaria pre-erythrocytic vaccine lsa-3 and refinement of measurable outcomes (EMLI)

Project information

Grant agreement ID: QLK2-CT-2001-01886

  • Start date

    1 January 2002

  • End date

    31 December 2007

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 967 554

  • EU contribution

    € 1 462 733

Coordinated by:

INSTITUT PASTEUR

France

Objective

This proposal is based on a decade of European-sponsored research, which led to the rational identification, characterization, and demonstration of protection in Chimpanzees by LSA3. It aims at testing, in phase-I and conditional phase-II trials, the protective effect demonstrated in the primate genetically 98,4% similar to humans. Besides safety and immunogenicity, it includes a unique approach to the understanding of critical mechanism of defence in the liver, aimed at improving surrogates to guide future vaccine development. Three novel vaccine delivery systems will be used: Lactococcus lactic recombinant protein in the new SBAS2 adjuvant from SB Bio, DKA immunisation with the Adventism Pasteur licensed Vocal vector, lip peptide immunisation without adjuvant, yet another recent European discovery. It is performed witch the expert guidance of he 2 leading vaccine industries.

Coordinator

INSTITUT PASTEUR

Address

Rue Du Docteur Roux 28
75724 Paris

France

Participants (8)

AVENTIS PASTEUR SA

France

BACHEM FEINCHEMIKALIEN AG@@@

Switzerland

GLAXOSMITHKLINE BIOLOGICALS SA

Belgium

HENOGEN S.A.

Belgium

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

UNIVERSIDAD DEL VALLE

Colombia

UNIVERSITY OF LAUSANE

Switzerland

Project information

Grant agreement ID: QLK2-CT-2001-01886

  • Start date

    1 January 2002

  • End date

    31 December 2007

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 967 554

  • EU contribution

    € 1 462 733

Coordinated by:

INSTITUT PASTEUR

France