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The key role of complement mblectin pathway in infectious and chronic disease (COMPLEMENT IN DISEASE)

The key role of complement mblectin pathway in infectious and chronic disease (COMPLEMENT IN DISEASE)

Objective

Human resistance to microbial infection is mediated by humoral and cellular effector systems. A major part of the humoral immune system is complement which consists of 30-35 proteins that recognize and are of utmost importance for the elimination of viruses, bacteria, fungi and parasites. Diminished complement activity causes humans to become susceptible to repetitive fulminant or severe infections. In the concerted action BMH4-CT96-1005, we analysed the contribution of two pathways of complement in detail and provided evidence that these pathways have essential roles in chronic autoimmune, inflammatory and infectious diseases. More recently a third pathway of complement activation was uncovered. There is a strong suggestion that this pathway is crucial in recognition and clearance of pathogenic microorganisms. It is the purpose of this project to delineate the relative contribution of the MBL pathway in autoimmune and infectious disease.

Coordinator

LEIDEN UNIVERSITY

Address

Albinusdreef 2
2333 Za Leiden

Netherlands

Administrative Contact

Huub. G. CARBO (Dr)

Participants (9)

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ARISTOTLE UNIVERSITY OF THESSALONIKI

Greece

COPENHAGEN UNIVERSITY HOSPITAL

Denmark

JOHANNES GUTENBERG UNIVERSITAET MAINZ

Germany

LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK

Austria

MEDICAL RESEARCH COUNCIL

United Kingdom

NORDLAND CENTRAL HOSPITAL

Norway

UNIVERSITY COLLEGE LONDON

United Kingdom

UNIVERSITÀ DEGLI STUDI DI TRIESTE

Italy

WIESLAB AB

Sweden

Project information

Grant agreement ID: QLG1-CT-2001-01039

  • Start date

    1 January 2002

  • End date

    31 December 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 435 659

  • EU contribution

    € 435 659

Coordinated by:

LEIDEN UNIVERSITY

Netherlands