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Nmr tools for the study of transient intermediates in biomolecular processes

Nmr tools for the study of transient intermediates in biomolecular processes

Objective

Objectives: The proposal aims at the development of dedicated NMR probes and the accompanying NMR tools for the structure determination of rapidity formed, short-lived intermediates that are important in biological processes. These transient intermediates can be induced in a biomolecular system by photochemical means or by a rapid change of solvent conditions. Therefore, both a rapid mixing and a laser coupled probe will be made in which all modern multidimensional NMR experiments including the use of pulsed field gradients are possible, with as little compromise on the NMR performance as possible. These NMR probes and the set of developed experimental methods will be validated for photobiology, in protein and RNA folding studies, and in CIDNP experiments.

Results: Project Manager: Robert Kaptein NMR Spectroscopy, Bijvoet Center for Biomolecular Research Padualaan 8 Utrecht 3584-CH The Netherlands Tel: 31-30 2533787 Fax: 31-30 2537623 E-Mail: kaptein@nmr.chem.uu.nl

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Coordinator

UTRECHT UNIVERSITY

Address

8,Padualaan 8
3584 Ch Utrecht

Netherlands

Administrative Contact

Paul HERMANS (M.Sc.)

Participants (3)

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CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE

Italy

JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT

Germany

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Project information

Grant agreement ID: HPRI-CT-1999-50006

  • Start date

    1 March 2000

  • End date

    27 February 2004

Funded under:

FP5-HUMAN POTENTIAL

  • Overall budget:

    € 1 080 000

  • EU contribution

    € 900 000

Coordinated by:

UTRECHT UNIVERSITY

Netherlands