Skip to main content

An integrated analysis of links between pathways of rna metabolism in the post-genomic era (RNOMICS)

Objective

RNA metabolism is central to gene expression and to its regulation. The functional analysis of genomes depends upon a good understanding of RNA metabolism to facilitate annotation of gene structure and to understand many of the pathways involved in gene expression. Starting with a large database of protein-protein interactions involved in RNA metabolism, combined with genomic sequence data, we will apply systematic functional analyses to study various aspects of RNA metabolism and how these are interlinked and integrated with other cellular processes. European laboratories with expertise in different aspects of RNA metabolism will collaborate to develop and apply functional genomic and bio-informatics tools to produce an integrated database representing genetic, physical and functional data on RNA metabolic pathways and how these communicate with other cellular processes. In the database there will be a strong emphasis on comparing yeast and mammalian systems. Novel data that may be relevant to genetic disorders or pathogenic organisms will be disseminated or, where appropriate, exploited commercially.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (4)

FUNDACAO DA UNIVERSIDADE DE LISBOA
Portugal
Address
Avenida Prof. Egas Moniz
1649-028 Lisboa
HYBRIGENICS
France
Address
Impasse Reille 3-5
75014 Paris
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 28
75724 Paris
UNIVERSITAET BASEL
Switzerland
Address
Klingelbergstrasse 70
4056 Basel