RNA metabolism is central to gene expression and to its regulation. The functional analysis of genomes depends upon a good understanding of RNA metabolism to facilitate annotation of gene structure and to understand many of the pathways involved in gene expression. Starting with a large database of protein-protein interactions involved in RNA metabolism, combined with genomic sequence data, we will apply systematic functional analyses to study various aspects of RNA metabolism and how these are interlinked and integrated with other cellular processes. European laboratories with expertise in different aspects of RNA metabolism will collaborate to develop and apply functional genomic and bio-informatics tools to produce an integrated database representing genetic, physical and functional data on RNA metabolic pathways and how these communicate with other cellular processes. In the database there will be a strong emphasis on comparing yeast and mammalian systems. Novel data that may be relevant to genetic disorders or pathogenic organisms will be disseminated or, where appropriate, exploited commercially.
Funding SchemeCSC - Cost-sharing contracts