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Optimisation and control of the freeze-drying of pharmaceutical proteins

Optimisation and control of the freeze-drying of pharmaceutical proteins

Objective

The aim is to optimise the freeze-drying process of pharmaceutical proteins on a scientific basis, using a new technology to control ice nucleation; an innovative piece of equipment will be realised, developing new control and diagnostic tool and new sensors. This will improve the performances and the reproducibility of the process, allowing to control the final quality of the product, increasing competitively of European pharmaceutical industry and producers of freeze-dryers. The production of therapeutic proteins in lyophilised form will be greatly improved, reducing the possibility of antigenic effects. It will be possible to design prolonged-release injectable forms of proteins using an advanced supercritical coating technology, with lower treatment cost and improvement in the patient's comfort. Another objective is the reduction of waste product in the production of serological screening tests.

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Coordinator

POLITECNICO DI TORINO

Address

Corso Duca Degli Abruzzi 24
10129 Torino (Turin)

Italy

Administrative Contact

Giovanni DEL TIN (Prof.)

Participants (8)

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ALFA WASSERMANN SPA

Italy

ASYMPTOTE LTD

United Kingdom

BIOMERIEUX SA

France

ETHYPHARM

France

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

TELSTAR INDUSTRIAL S.L.

Spain

UNIVERSITE CLAUDE BERNARD LYON 1

France

UTRECHT UNIVERSITY

Netherlands

Project information

Grant agreement ID: G1RD-CT-2002-00736

  • Start date

    1 April 2002

  • End date

    31 March 2005

Funded under:

FP5-GROWTH

  • Overall budget:

    € 3 450 412

  • EU contribution

    € 1 945 244

Coordinated by:

POLITECNICO DI TORINO

Italy

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