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Iron in hemochromatosis : deleterious effects of an essential nutrient

Objective

Normal dietary iron causes organ damage in patients with homozygous Hereditary Hemochromatosis (HH). Heterozygotes (10% of the European population) are at risk for early cardiovascular death. HH patients absorb too much iron and have toxic non-transferring-bound iron (NTBI) in plasma. This project intends to identify the mechanism of TBI toxicity, and the damage to vascular endothelium (as target for arteriosclerosis) and to the liver. An inexpensive method for NTBI measurement will be developed. Oral iron chelator will be developed to inhibit excess absorption of iron and to scavenge NTBI. Iron absorption, as a key pathogenic mechanism, will be analysed at a molecular level. The project is expected to result in less organ damage and in prevention of early death in HH patients.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY MEDICAL CENTRE UTRECHT
Address
Heidelberglaan 100, Azu G04.515
3584CX Utrecht
Netherlands

Participants (6)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue Henrile Guilloux 2
35033 Rennes
KING'S COLLEGE LONDON
United Kingdom
Address
Coldharbour Lane 123
SE5 9NU London
SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH
Switzerland
Address
Hoenggerberg, Hci
8093 Zurich
THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT
Israel
Address
Givat Ram Campus
91904 Jerusalem
UNIVERSITY OF MODENA AND REGGIO EMILIA
Italy
Address
Largo Del Pozzo 71
41100 Modena
UNIVERSITÉ DE RENNES 1
France
Address
Rue Henri Le Guilloux 2
35033 Rennes