CORDIS
EU research results

CORDIS

English EN
The occurrence, detection and treatment of adenovirus infection in patients undergoing allogeneic stem cell transplantation

The occurrence, detection and treatment of adenovirus infection in patients undergoing allogeneic stem cell transplantation

Objective

Future progress in hemopoietic stem cell transplantation is hampered by disseminated adenoviral (AdV) infection, which is estimated to kill 175 transplant patients in EU yearly. Current virological tests are poor either for predicting those patients who will develop life threatening AdV disease or evaluating the efficacy of antiviral drugs. We therefore propose to perform rapid, sensitive quantitation of plasma adenoviral DNA load in a multi-centre prospective study using Real -Time Quantitative PCR (RQ-PCR) for disease monitoring, prognostication and monitoring of responses to antiviral drugs, in conjunction with pharmacokinetic/dynamic studies and in vitro AdV sensitivity. AdV-specific T-cell reactivity and neutralizing antibodies will be measured in all patients to explore the feasibility of immunotherapy. Based on the data a protocol for the management of AdV infections in immunocompromised hosts will be delivered to the community.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

LEIDEN UNIVERSITY

Address

Albinusdreef 2
2333 Al Leiden

Netherlands

Administrative Contact

Rene VAN LIESHOUT (Dr)

Participants (4)

Sort alphabetically

Expand all

INSTITUTE OF HAEMATOLOGY AND BLOOD TRANSFUSION

Czechia

UNIVERSITE CLAUDE BERNARD LYON 1

France

UNIVERSITY OF BRISTOL

United Kingdom

UTRECHT UNIVERSITY

Netherlands

Project information

Grant agreement ID: QLK2-CT-2002-01432

  • Start date

    1 September 2002

  • End date

    30 November 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Coordinated by:

LEIDEN UNIVERSITY

Netherlands