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Design of novel inhibitors of hcv rna helicase - potential antivirals for treatment and protection against hepatitis c virus-induced diseases (HCV INHIBITORS)

Project information

Grant agreement ID: QLK2-CT-2002-01079

  • Start date

    1 September 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 195 224

  • EU contribution

    € 986 997

Coordinated by:

INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES

Poland

Objective

Hepatitis C virus (HCV) infections lead to liver cirrhosis and hepatocellular carcinoma. Currently no efficient drug or vaccine is available. A team of 6 European laboratories from D, F, PL will synthesise and investigate the psycho-chemical and biological properties of a broad range of new modified nucleoside derivatives, guanine, trampoline and anthracycline analogy and their prod rugs, potential inhibitors of HCV RNA helices, a novel and promising target for anti- HCV therapy. The interactions of analogy with HCV helices will be investigated with the use of kinetic methods, crystallography, and multidimensional NMR and CD spectroscopy. Inhibitory activity against HCV helices will be verified in vitro in HCV-infected human macrophages, in human hepatocytes and in yeast cell system. This research should deliver new anti-HCV drugs and may improve the quality of life of millions of HCV-infected patients.

Coordinator

INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES

Address

Pawinskiego 5a
02-106 Warszawa

Poland

Participants (5)

BERNHARD NOCHT INSTITUT FUER TROPENMEDIZIN

Germany

FREIE UNIVERSITAET BERLIN

Germany

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

INSTITUTE OF ORGANIC INDUSTRY

Poland

INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ POLSKIEJ AKADEMII NAUK

Poland

Project information

Grant agreement ID: QLK2-CT-2002-01079

  • Start date

    1 September 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 195 224

  • EU contribution

    € 986 997

Coordinated by:

INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES

Poland