The goal of the project is to develop new in-vitro platforms for pharmaceutical screening based on animal or human cells grown on microelectrode arrays enabling simultaneous monitoring of extra- and intracellular levels of key metabolites (e.g., NO and super oxide) by using optic- electrochemical techniques. By individually addressing the electrodes of the arrays the toxicity of bio medically relevant substances can be studied with increased spatial resolution and without disturbing the living cells. The proposed in-vitro testing platforms address development of high throughput screening for detecting toxicity and development of in-vitro toxicity tests for assessing local toxicity and toxicology-toxicology. By bringing together modern technologies a novel integrated generic measurement platform will be developed to monitor metabolites in cultured cell lines and primary cells, vital for rapid drug discovery.
Funding SchemeCSC - Cost-sharing contracts
UB3 1HH Hayes,middlesex
581 83 Linkoeping
611 37 Brno
NE1 7RU Newcastle Upon Tyne