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Novel in vitro testing platforms based on intra-and extracellular sensing

Objective

The goal of the project is to develop new in-vitro platforms for pharmaceutical screening based on animal or human cells grown on microelectrode arrays enabling simultaneous monitoring of extra- and intracellular levels of key metabolites (e.g., NO and super oxide) by using optic- electrochemical techniques. By individually addressing the electrodes of the arrays the toxicity of bio medically relevant substances can be studied with increased spatial resolution and without disturbing the living cells. The proposed in-vitro testing platforms address development of high throughput screening for detecting toxicity and development of in-vitro toxicity tests for assessing local toxicity and toxicology-toxicology. By bringing together modern technologies a novel integrated generic measurement platform will be developed to monitor metabolites in cultured cell lines and primary cells, vital for rapid drug discovery.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LUND UNIVERSITY
Address
Paradisgatan 2
221 00 Lund
Sweden

Participants (9)

BAR ILAN UNIVERSITY
Israel
Address
Bar-ilan University
Ramat Gan
CENTRAL RESEARCH LABORATORIES LIMITED
United Kingdom
Address
Dawley Road Hayes
UB3 1HH Hayes,middlesex
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
75794 Paris
IVAX DRUG RESEARCH INSTITUTE LTD
Hungary
Address
Berlini, 47-49
1045 Budapest
LINKOEPING UNIVERSITY
Sweden
Address
Hus Origo Campus Valla
581 83 Linkoeping
RUHR-UNIVERSITY BOCHUM
Germany
Address
Universitaetsstrasse 150
44780 Bochum
UNIVERSITE DE NEUCHATEL
Switzerland
Address
Avenue Du 1Er Mars, 26
2000 Neuchatel
UNIVERSITY MASARYK IN BRNO
Czechia
Address
2,Kotlarska 2
611 37 Brno
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address

NE1 7RU Newcastle Upon Tyne