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Severe streptococcus pyogenes disease in europe

Project information

Grant agreement ID: QLK2-CT-2002-01398

  • Start date

    1 September 2002

  • End date

    31 August 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 354 625

  • EU contribution

    € 1 199 139

Coordinated by:

LUND UNIVERSITY

Sweden

Objective

The main objective is to improve understanding of the epidemiology of severe group a streptococcal (GAS; Streptococcus pyogenes) disease in Europe. To achieve an integrated picture of these infections, molecular methods for typing and clonal identification of clinical isolates will be used. Strains will also be analysed for antibiotic susceptibility, and resistance determinants will be traced. A novel class of antibacterial synthetic oligopeptides will be evaluated for efficacy in invasive GAS disease, and the mechanism of action will be studied. Furthermore, pathogenic aspects of severe GAS disease, such as proteolytic activation of the contact system, and selected virulence factors, such as surface proteins and superantigens, will be investigated.

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Coordinator

LUND UNIVERSITY

Address

Soelvegatan 23
22100 22362

Sweden

Participants (11)

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

CANTACUZINO INSTITUTE

Romania

HEALTH PROTECTION AGENCY

United Kingdom

HOSPITAL ARCHBISHOP MAKARIOS III

Cyprus

ISTITUTO SUPERIORE DI SANITA

Italy

NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

Greece

NATIONAL INSTITUTE OF PUBLIC HEALTH

Czechia

NATIONAL PUBLIC HEALTH INSTITUTE

Finland

SMITTSKYDDSINSTITUTET

Sweden

STATENS SERUM INSTITUT

Denmark

UNIVERSITAETSKLINIKUM AACHEN

Germany

Project information

Grant agreement ID: QLK2-CT-2002-01398

  • Start date

    1 September 2002

  • End date

    31 August 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 354 625

  • EU contribution

    € 1 199 139

Coordinated by:

LUND UNIVERSITY

Sweden