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Prevalidation of novel alternative pharma-/toxicological screening based on yeast expression technology

Prevalidation of novel alternative pharma-/toxicological screening based on yeast expression technology

Objective

The project aims to the revalidation of a novel alternative pharma-/toxicologicalscreening on potassium channels involved in human diseases based on yeast expression. Ion channels conduct the nerve impulses and mediate the effects of many signal molecules. Potassium (K) channels are by far the most diverse group onion channels known and participate in a wide range of physiological responses. Inmost cells they are responsible for maintaining the resting potential. In excitable tissue currents mediated by K channels underlie the depolarisation of the action potential. Severe diseases connected to K channel dysfunction are ventriculartachycardia, hypertension, deafness and metabolic disorders. The yeast-based screening technology will provide a reliable system for pharmacy- /toxicological analysis and a bioassay for rapid identification of chemical and pharmaceutical compounds and has thus the potential to reduce the need for animal experimentation.

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Coordinator

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN

Address

Regina Pacis Weg 3
Bonn

Germany

Administrative Contact

Reinhard LUTZ

Participants (6)

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ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

NEUROSEARCH AS

Denmark

STEINBEIS TECHNOLOGY TRANSFER CENTER FOR IN-VITRO PHARMACOLOGY AND TOXICOLOGY

Germany

THE UNIVERSITY OF TUEBINGEN

Germany

UNIVERSITY OF COPENHAGEN

Denmark

University of York

United Kingdom

Project information

Grant agreement ID: QLK3-CT-2001-00401

  • Start date

    1 January 2002

  • End date

    30 June 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 134 390

  • EU contribution

    € 1 736 666

Coordinated by:

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN

Germany