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Heat shock protein 60 as a novel therapeutic target for diabetes and rheumatoid arthritis (HSPFORTHERAPY)

Heat shock protein 60 as a novel therapeutic target for diabetes and rheumatoid arthritis (HSPFORTHERAPY)

Objective

Heat shock proteins are antigens of immune responses in autoimmunity. In experimental models they suppress inflammation and in clinical trials in diabetes and arthritis hsp60 has a proven therapeutic potential. We propose to analyse the underlying mechanisms by monitoring immunity to hsp60 in the models, in patients and during hsp60 peptide trials, with respect to both the adaptive and the innate part of the immune system.

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Coordinator

UTRECHT UNIVERSITY

Address

Yalelaan 1
3584 Cl Utrecht

Netherlands

Administrative Contact

Gommarus A. VAN STRIEN (Ir.Drs.)

Participants (5)

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DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT E.V.

Germany

PEPTOR LTD

Israel

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

UNIVERSITY MEDICAL CENTRE UTRECHT

Netherlands

WEIZMANN INSTITUTE OF SCIENCE

Israel

Project information

Grant agreement ID: QLG1-CT-2002-01287

  • Start date

    1 September 2002

  • End date

    30 June 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 409 275

  • EU contribution

    € 1 299 892

Coordinated by:

UTRECHT UNIVERSITY

Netherlands

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