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Molecular mechanisms of disease progression and renoprotective pharmacotherapy in children with chronic renal failure

Objective

ACE inhibitors are renoprotective in adults with chronic renal failure (CRF), but of unproven usefulness in children. In a randomised trial in 350 CRF children we will address if ACE inhibition is efficacious in slowing CRF progression in acquired and congenital nephropathies, if progression can be additionally influenced by intensified antihypertensive treatment achieving low-normal blood pressure, and which factors determine CRF progression and/or its susceptibility to ACE inhibition. Potential effects of renin-angiotensin system and PAI-l gene polymorphisms, mutations in genes defining glomerular structure or causing renal hypo/dysplasia, renal endothelnr-l turnover, plasma homocysteine and apolipoprotein phenotypes will be assessed. The cardiovascular consequences of childhood-onset CRF and renoprotective pharmacotherapy will be addressed by carotid ultrasound, echocardiography and 24-hour blood pressure monitoring.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG
Address
Im Neuenheimer Feld 150
69115 Heidelberg
Germany

Participants (27)

AZIENDA OSPEDALIERA AUTONOMA - SANT'ANNA - O.I.R.M. TORINO
Italy
Address
Piazza Polonia, 94
10126 Torino (Turin)
AZIENDA OSPEDALIERA DI PADOVA
Italy
Address
Via Giustiniani 3
35128 Padova
AZIENDA OSPEDALIERA ISTITUTI CLINICI DI PERFEZIONAMENTO
Italy
Address
Via Della Commenda 9
20122 Milano
CERRAHPASA MEDICAL FACULTY
Turkey
Address
Kocamustafapasa
34303 Istanbul
CHILDREN'S MEMORIAL HEALTH INSTITUTE
Poland
Address
Aleja Dzieci Polskich 20
04 736 Warszawa
HACETTEPE UNIVERSITY
Turkey
Address
Sihhiye
06100 Ankara
HANNOVER MEDICAL SCHOOL
Germany
Address
Carl-neuberg-strasse 1
30625 Hannover
HOPITAUX UNIVERSITAIRES DE STRASBOURG
France
Address
Avenue Moliere
67098 Strasbourg
HOSPITAL SAO JOAO
Portugal
Address
Alameda Prof. Hernani Monteiro
4202-451 Porto
HUDDINGE UNIVERSITY HOSPITAL
Sweden
Address

141 86 Huddinge
HUMBOLDT-UNIVERSITAET BERLIN
Germany
Address
Schumannstrasse 20/21
10117 Berlin
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Sevres 149-161
75743 Paris
ISTANBUL MEDICAL FACULTY
Turkey
Address
Capa
34390 Istanbul
ISTITUTO GIANNINA GASLINI
Italy
Address
Largo Gerlamo Gaslini 5
16148 Genova
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Langenbeckstrasse 1
55101 Mainz
PAEDIATRIC HOSPITAL BAMBINO GESU
Italy
Address
4,Piazza Sant' Onofrio 4
00165 Roma
PHILIPPS UNIVERSITY MARBURG
Germany
Address
Deutschhausstrasse 12
35043 Marburg
POMERANIAN MEDICAL ACADEMY
Poland
Address
Unii Lubelskiej 1
70 954 Szczecin
SEMMELWEIS UNIVERSITY OF MEDICINE
Hungary
Address
Bokay Janos U. 53
1083 Budapest
STAEDLISCHES KLINIKUM ST. GEORG
Germany
Address
Delitzscher Strasse 141
04129 Leipzig
UNIVERSITAETSKLINIKUM ESSEN, ANSTALT DES OFFENTLICHEN RECHTS
Germany
Address
Hufelandstrasse 55
45122 Essen
UNIVERSITY CHILDREN'S HOSPITAL
Switzerland
Address
Steinwiesstr. 75
8032 Zurich
UNIVERSITY HOSPITAL HAMBURG-EPPENDORF
Germany
Address
C/o University Children's Hospital, Martinistrasse
20246 Hamburg
UNIVERSITY HOSPITAL MOTOL
Czechia
Address
V Uvalu 84
150 06 Praha 5
UNIVERSITY OF BELGRADE
Address
Tirsova 10
11000 Belgrade
UNIVERSITY OF CUKUROVA
Turkey
Address
Balcali
01330 Adana
UNIVERSITY OF EGE
Turkey
Address
Ege Universitesi Kampusu
35040 Bornova