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Molecular analysis and mechanistic elucidation of the functionality of probiotics and prebiotics in the inhibition of pathogenic microorganisms to combat gastrointestinal disorders and to improve human health

Objective

Recently, much attention is paid to the health-promoting properties of Lactobacilli and Bifid bacteria. Prebiotics and probiotics are the driving forces of the functional foods market. However, a major problem is that many of these health-promoting properties are still questioned. For instance, the fundamental basis of the inhibition of Gram-negative pathogenic bacteria - like the entero-virulent diarrheagenic Salmonellae, and Helicobacter pylori causing gastrointestinal disorders - by probiotic lactic acid bacteria has not been elucidated. This project will focus on the identification of the responsible compounds. In addition, the mechanism of the inhibition of Gram-negative pathogens by probiotic Lactobacilli and Bifid bacteria will be studied using co culture models (simulated gut fermentations, human cell lines and animal models). Clinical studies will be performed too.

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Coordinator

VRIJE UNIVERSITEIT BRUSSEL

Address

2,Bd De La Plaine 2
1050 Bruxelles

Belgium

Participants (6)

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AGRICULTURAL UNIVERSITY OF ATHENS

Greece

AGRICULTURAL UNIVERSITY OF NORWAY

Norway

BELDEM S.A.

Belgium

DEXTER COM S.R.L.

Romania

HELLENIC PASTEUR INSTITUTE

Greece

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Project information

Grant agreement ID: QLK1-CT-2001-01179

  • Start date

    1 January 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 636 484

  • EU contribution

    € 1 310 600

Coordinated by:

VRIJE UNIVERSITEIT BRUSSEL

Belgium

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