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Molecular analysis and mechanistic elucidation of the functionality of probiotics and prebiotics in the inhibition of pathogenic microorganisms to combat gastrointestinal disorders and to improve human health

Objective

Recently, much attention is paid to the health-promoting properties of Lactobacilli and Bifid bacteria. Prebiotics and probiotics are the driving forces of the functional foods market. However, a major problem is that many of these health-promoting properties are still questioned. For instance, the fundamental basis of the inhibition of Gram-negative pathogenic bacteria - like the entero-virulent diarrheagenic Salmonellae, and Helicobacter pylori causing gastrointestinal disorders - by probiotic lactic acid bacteria has not been elucidated. This project will focus on the identification of the responsible compounds. In addition, the mechanism of the inhibition of Gram-negative pathogens by probiotic Lactobacilli and Bifid bacteria will be studied using co culture models (simulated gut fermentations, human cell lines and animal models). Clinical studies will be performed too.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

VRIJE UNIVERSITEIT BRUSSEL
Address
2,Bd De La Plaine 2
1050 Bruxelles
Belgium

Participants (6)

AGRICULTURAL UNIVERSITY OF ATHENS
Greece
Address
Iera Odos 75
11855 Athens
AGRICULTURAL UNIVERSITY OF NORWAY
Norway
Address
Meieribygningen
1432 Aas
BELDEM S.A.
Belgium
Address
Rue Bourrie 12
5300 Andenne,seilles
DEXTER COM S.R.L.
Romania
Address
Popa Rusu N°6 Ap 6
7022 Bucharest
HELLENIC PASTEUR INSTITUTE
Greece
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris