Objective This proposal is a combined R&D and demonstration project aimed at developing a novel therapeutic substance effective as cancer vaccine. The consortium has a unique expertise in a novel cell free vaccine i.e. the exosomes, 60-90 nm antigen presenting membrane vesicles of endosomal origin, secreted by antigen presenting cells. Characterization of exosome bioactivity will allow neosynthesis of biovectors endowed with targeting and tumor antigen transfer capacities to antigen presenting cells for active immunization. R&D objectives will be to:1) define the biogenesis and biochemica composition of exasomes.2) investigate their in vitra and in viva functians.3) optimise the immunizing strategy using exosomes in preclinical tumor studies4) design "universal" exosome based-cancer vaccine using good manufactoring procedures.Demonstration phase involving the SME will show exosome safety and efficacy in immunizing metastatic cancer bearing patients. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesmedical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme DEM - Demonstration contracts Coordinator INSTITUT GUSTAVE ROUSSY EU contribution No data Address France See on map Links Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution No data Address Rapenburg 70 2311 EZ LEIDEN See on map Total cost No data ANOSYS S.A. France EU contribution No data Address Rue Pierre Fontaine, 1 91058 EVRY See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue Lhomond 12 75005 PARIS See on map Total cost No data UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA Italy EU contribution No data Address Piazza della Scienza 2 20126 MILANO See on map Total cost No data VELINDRE HOSPITAL NHS TRUST United Kingdom EU contribution No data Address Velindre Road, Whitchurch CF14 2TL CARDIFF See on map Total cost No data