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Biochemical and functional characterization of antigen presenting cell derived-exosomes: the design of a cell free cancer vaccine

Project information

Grant agreement ID: QLK3-CT-2001-00093

  • Start date

    1 January 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 4 382 838

  • EU contribution

    € 1 909 090

Coordinated by:

INSTITUT GUSTAVE ROUSSY

France

Objective

This proposal is a combined R&D and demonstration project aimed at developing a novel therapeutic substance effective as cancer vaccine. The consortium has a unique expertise in a novel cell free vaccine i.e. the exosomes, 60-90 nm antigen presenting membrane vesicles of endosomal origin, secreted by antigen presenting cells. Characterization of exosome bioactivity will allow neosynthesis of biovectors endowed with targeting and tumor antigen transfer capacities to antigen presenting cells for active immunization. R&D objectives will be to:
1) define the biogenesis and biochemica composition of exasomes.
2) investigate their in vitra and in viva functians.
3) optimise the immunizing strategy using exosomes in preclinical tumor studies
4) design "universal" exosome based-cancer vaccine using good manufactoring procedures.

Demonstration phase involving the SME will show exosome safety and efficacy in immunizing metastatic cancer bearing patients.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

INSTITUT GUSTAVE ROUSSY

Address

France

Participants (5)

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

ANOSYS S.A.

France

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA

Italy

VELINDRE HOSPITAL NHS TRUST

United Kingdom

Project information

Grant agreement ID: QLK3-CT-2001-00093

  • Start date

    1 January 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 4 382 838

  • EU contribution

    € 1 909 090

Coordinated by:

INSTITUT GUSTAVE ROUSSY

France