Objective In animals substantial prevention of allergy can be achieved by inhalation of microbial products. It is unknown whether such findings can be brought forward to humans, but findings in farmers' children raised in environments rich in microbial matter suggest that these children constitute an ideal 'natural' model to study these relations in humans. Recent retrospective surveys clearly indicated that exposures must occur in pregnancy and the 1st Year of life to confer significant protection, resulting in very low prevalence's of asthma (0.8% vs. 11.8%), hay fever (0.8% vs. 16.0%) and atop (8.2% vs. 32.9%) as compared to non-exposed children. The project therefore focuses on early life exposures to indoor microbial matter in a prospective study design. A multidisciplinary approach is taken to study immunological and genetic mechanisms determining the strong protective effects, which will allow the development of novel preventive strategies. Fields of science medical and health sciencesclinical medicinepneumologyasthmamedical and health sciencesclinical medicineobstetricsagricultural sciencesagriculture, forestry, and fisheriesagricultureindustrial cropsfoddermedical and health sciencesclinical medicineallergology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH EU contribution No data Address Lindwurmstrasse 4 80337 MUENCHEN Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all AMT DER SALZBURGER LANDESREGIERUNG Austria EU contribution No data Address Muellner Haupstrasse 48 5020 SALZBURG See on map Total cost No data NATIONAL PUBLIC HEALTH INSTITUTE Finland EU contribution No data Address 4,Neulaniementie 4 70210 KUOPIO See on map Total cost No data PHILIPPS UNIVERSITY MARBURG Germany EU contribution No data Address Baldingerstrasse 1 35033 MARBURG See on map Total cost No data UNIVERSITAET BASEL Switzerland EU contribution No data Address 49,Steinengraben 49 4051 BASEL See on map Total cost No data UNIVERSITAETSKLINIKUM ULM Germany EU contribution No data Address SYRLINSTRASSE 38 89073 ULM See on map Total cost No data UNIVERSITY OF ZURICH Switzerland EU contribution No data Address Steinwiesstrasse 75 8032 ZURICH See on map Total cost No data
