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Evaluation of lentivirus dna vaccination strategies in sheep

Evaluation of lentivirus dna vaccination strategies in sheep

Objective

Lentivirus vaccines have proven difficult to develop to date. The reasons for this include a lack of information on target antigens, protective immune responses, and effective vaccine strategies. We propose to evaluate DNA vaccination strategies in sheep challenged with maedi visna virus (MVV). Sheep will be immunised with MVV core or envelope genes or a combination of these via the skin (by gene gun) or mucosal tissues (using Salmonella vehicles). The effects of including genes encoding IFNg or IL4 during priming will also be investigated. Animals will be boosted with recombinant Adenovirus encoding the MVV genes. Immunological variables as well as virus load and disease will be determined before and after challenge. The project will help to identify protective virus antigens, provide useful information on immune correlates of protection, and indicate whether mucosal or cutaneous immunisation correlates with protection.

Coordinator

UNIVERSITY OF EDINBURGH

Address

Summerhall
Eh9 1qh Edinburgh

United Kingdom

Administrative Contact

Robert SMAILES (Dr)

Participants (9)

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AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS

France

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

UNIVERSIDAD DE ZARAGOZA

Spain

UNIVERSITA DEGLI STUDI DI PISA

Italy

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

UNIVERSITY OF ICELAND

Iceland

UNIVERSITY OF TORINO

Italy

University of Cambridge

United Kingdom

Project information

Grant agreement ID: QLK2-CT-2002-00617

  • Start date

    1 September 2002

  • End date

    28 February 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 200 097

  • EU contribution

    € 1 701 759

Coordinated by:

UNIVERSITY OF EDINBURGH

United Kingdom

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