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The role of chemokines in the pathogenesis of atopic eczema

Project information

Grant agreement ID: QLK4-CT-2001-00366

  • Start date

    1 January 2002

  • End date

    31 December 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 461 700

  • EU contribution

    € 1 749 924

Coordinated by:

UNIVERSITY OF HELSINKI

Finland

Objective

Atomic dermatitis (AD) is inflammatory skin disease with a high prevalence and increasing incidence. Cherokees have recently been identified as the key players of tissue-specific immune responses. We propose to apply state of the art knowledge, techniques and a unique murine model of AD to examine the role ofchemokines and their receptors in the pathogenesis of AD. We will:
I) characterizechemokines/receptors involved in disease initiation, progress and chronification.
II) Functional relevance of chamomiles/receptors will be determined in vivo by means of a murine AD model utilizing neutralizing antibodies and knockout mice. Finally,
III) Regulation of chamomile/receptor expression by external and intrinsic factors in AD will be explored. Results of this study will identify novel targets for the development of more selective treatments for AD with putatively less side effects and good patient compliance.

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Coordinator

UNIVERSITY OF HELSINKI

Address

Haartmaninkau, 8
00014 Helsinki

Finland

Participants (4)

FINNISH INSTITUTE OF OCCUPATIONAL HEALTH

Finland

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITY OF SZEGED

Hungary

Project information

Grant agreement ID: QLK4-CT-2001-00366

  • Start date

    1 January 2002

  • End date

    31 December 2004

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 461 700

  • EU contribution

    € 1 749 924

Coordinated by:

UNIVERSITY OF HELSINKI

Finland