Objective A newly discovered virus, human metapneumovirus (hMPV), responsible for respiratory disease in young children, is closely related to subgroup C isolates of the prototype metapneumovirus, avian pneumovirus (APV). APV is a major cause of significant economic losses in the poultry industry in Europe. Current diagnostic techniques cannot detect these metapneumoviruses and as a result the significance and distribution of hMPV subgroup C APV are not known. Thus the burden of disease from these agents cannot be assessed. The proposal addresses these problems by generating new, standardised, detection and characterisation assays, developed for commercial use. Using reverse genetics techniques for both hMPV and APV, the molecular biology, aspects of pathogenicity and host specificity will be analysed This will also generate recombinant viruses which will be the foundation for future rational vaccine design. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesmolecular biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF WARWICK EU contribution No data Address GIBBET HILL ROAD COVENTRY United Kingdom See on map Links Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS France EU contribution No data Address 22440 PLOUFRAGAN See on map Total cost No data ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address 50,Dr. Molewaterplein 50 Erasmus University Hospital 3015 GE ROTTERDAM See on map Total cost No data INMUNOLOGIA Y GENETICA APLICADA SA Spain EU contribution No data Address Hermanos Garcia Noblejas 41 MADRID See on map Links Website Opens in new window Total cost No data INSTITUTE OF HEALTH CARLOS III Spain EU contribution No data Address KM.2,Carretera de Majadahonda - Pozuelo KM.2 28220 MADRID See on map Total cost No data VIRONOVATIVE BV Netherlands EU contribution No data Address Burgemeester Oudlaan, 50 3062 PA ROTTERDAM See on map Total cost No data
