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Clinical features associated with tropheryma whipplei infection in an european setting - pathogenesis, diagnosis and treatment of whipple's disease

Clinical features associated with tropheryma whipplei infection in an european setting - pathogenesis, diagnosis and treatment of whipple's disease

Objective

Whipple's disease (WD) is a rare, multifactorial disease, in which the bacterium Tropheryma whipplei causes infections in predisposed hosts. We plan to set up the first multidisciplinary consortium to improve our understanding of the interaction of host, agent and environment in this disorder. This includes a coordinated collection of different tissues from WD patients and controls, studies of host factors (characterizing the underlying immunogenetic defect) and of environmental factors (occurrence of T. whipplei). In order to improve diagnosis, microbiologic characterization of the agent will include studies of growth conditions (allowing antibiotic susceptibility testing) and sequencing of the bacillus. Prospective therapy studies aim to improve the current antibiotic therapy and to test beneficial effects of new supportive treatments. This should lead to a significant improvement of the patients' disease burden.

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Coordinator

SAARLAND UNIVERSITY

Address

Kirrberger Str.
66421 Homburg

Germany

Administrative Contact

Margret WINTERMANTEL (Professor)

Participants (8)

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CHARITE UNIVERSITAETMEDIZIN BERLIN - CAMPUS BENJAMIN FRANKLIN

Germany

DRK KRANKENHAUS NEUWIED

Germany

EUROPEAN RESEARCH AND PROJECT OFFICE

Germany

IRCCS POLICLINICO SAN MATTEO - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

MEDICAL UNIVERSITY OF VIENNA

Austria

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

Project information

Grant agreement ID: QLG1-CT-2002-01049

  • Start date

    1 November 2002

  • End date

    31 October 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 364 861

  • EU contribution

    € 2 248 561

Coordinated by:

SAARLAND UNIVERSITY

Germany