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Identification and validation of molecular targets for pharmacological treatment of alcohol dependence (TARGALC)

Ziel

Proposal aim is to identify novel targets for pharmacological treatment of alcoholism. In an integrative approach, complementary expertise of 5 laboratories is applied. Pharmacologically validated animal models are adapted for generation of tissue from key brain regions. RNA is purified, and gene expression profiles established using Affymetrix methodology. An expression database is constructed, and mining the database identifies candidate genes differentially expressed in the functional models. Candidates are prioritised on the basis of available knowledge and availability of pharmacological tools, and confirmed using real time PCR and in site hybridisation. Confirmed targets are fed back into the functional models, where pharmacological and molecular manipulations of targets are evaluated for their ability to block alcohol drinking and reinstatement. Validated targets are patented and provide seeds for drug development.

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Data not available

Finanzierungsplan

CSC - Cost-sharing contracts

Koordinator

KAROLINSKA INSTITUTE
EU-Beitrag
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Adresse
Huddinge University Hospital
141 86 HUDDINGE
Schweden

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Beteiligte (4)

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Letzte Aktualisierung: 12 April 2005

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/QLG3-CT-2002-01048/de

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