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Multi-organic risk assessment of selected endocrine disrupters

Objective

ED's with steroidal or anti-steroidal effects may be of great importance during embryonic development and later for metabolic, brain, cardiovascular, reproductive, and bone function. The effects of UV-absorbing chemicals (4-MDC, homosalate), characterised recently as estrogenic, and of Benzophenone D, a chemical used in cosmetics, as well as the fungicide Procymidone and the pesticide Linuron will be studied in rats and gene-targeted mice. High throughput methods to identify ED's with (anti) estrogenic (anti) androgenic, (anti) progestational, (anti) glucocorticoid, and (anti) thyroid hormone activities will be employed. Gene-targeted cell lines and animals, including the EU-sponsored EUROSTERONE DNA chip, will seek to quantify both ED's and their effects on gene and protein expression in different organs. This will lead to clear concepts for clinical trials towards the end of the project.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN
Address
Robert-koch-strasse 40
37075 Goettingen
Germany

Participants (11)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
2Nd Floor, Irdb Building, Imperial College, Hammer
W12 ONN London
INSTITUTE OF ANIMAL REPRODUCTION AND FOOD RESEARCH - POLISH ACADEMY OF SCIENCES
Poland
Address
Prawochenskiego 5
10 718 Olstzyn
KAROLINSKA INSTITUTE
Sweden
Address
Novum Huddinge Sjukhus
141 86 Huddinge
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
Address
Ciudad Universitaria
28040 Madrid
UNIVERSIDAD DE BUENOS AIRES
Argentina
Address
Paraguay 2155, Piso 7
1121 Buenos Aires
UNIVERSITAETSKLINIKUM CHARITE - MEDIZINISCHE FAKULTAET DER HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
Address
Schumanstrasse 20-21
10117 Berlin
UNIVERSITY OF EDINBURGH
United Kingdom
Address
Chalmers Street 37
EH3 9ET Edinburgh
UNIVERSITY OF HELSINKI
Finland
Address
Haartmaninkatu 8, Biomedicum Helsinki
00014 Helsinki
UNIVERSITY OF MEDICAL SCIENCES K. MARCINKOWSKI
Poland
Address
6 Swiecicki Street
60 781 Poznan
UNIVERSITY OF TURKU
Finland
Address
Kiinamyllynkatu 13
20014 Turku
UNIVERSITY OF ZURICH
Switzerland
Address
Winterthurerstrasse 190
8057 Zurich