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EACH CHILD - a European-Asian challenge to childhood diarrhoea : design of a rapid diagnostic test for the most severe forms of childhood diarrhoea for use in peripheral health care centres in developing countries

Objective

Diarrhoeal diseases affect the poorest in the global family. WHO reports 4 billion cases of diarrhoea and 2 million deaths worldwide annually, primarily of children <5 years old in DCs. Most cases are acute and self-limiting if dehydration is avoided, but increasing numbers are due to enteropathogenic Escherichia coli (EPEC) and Shigella flexneri, which together account for 20% of diarrhoeal cases but 50% of deaths. EPEC causes persistent diarrhoea; Shigella causes dysentery. However, the early stages of both diseases are similar to acute diarrhoea, so it is not apparent that patients have EPEC infection until diarrhoea persists for 14 days, or Shigella infection until blood appears in the stools. By this time irreversible intestinal damage may have occurred, which, even if the child survives, may cause malnutrition, poor development, etc. that may manifest as socio-economic problems even in adulthood. The objective of Each Child is to develop a test kit for rapid early detection of EPEC and Shigella so that effective treatment can begin early enough to prevent potentially fatal intestinal damage and children' s lives can be saved - because Each Child is precious.

Call for proposal

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Coordinator

UNIVERSITY OF LEICESTER
EU contribution
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Address
Maurice Shock Building, University Road
LE1 9HN LEICESTER
United Kingdom

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Total cost
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Participants (3)