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Novel vaccination strategies and vaccine formulations for epidemic and pandemic influenza control

Novel vaccination strategies and vaccine formulations for epidemic and pandemic influenza control

Objective

Annual influenza epidemic and pandemic outbreaks of influenza cause a significant disease burden and mortality in man and have high economical impact in the EU. The major drawbacks of influenza vaccines are their limited efficacy and production methods that are hard to adapt to requirements of continuously changing influenza viruses. We aim to improve the efficacy and production methods of epidemic and pandemic influenza vaccines through
1) Improving epidemic vaccine strain selection based on retrospective and prospective analyses.
2) Improving vaccine strain selection and reference reagents for pandemic influenza.
3) Implementation of reverse genetics technologies to increase flexibility and yield of influenza vaccines.
4) Use of a cell substrate for vaccine production.
5) Use of novel antigen delivery systems.
6) Detailed examination of correlates of protection. Promising strategies will be tested in appropriate animal models.

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Coordinator

ERASMUS UNIVERSITEIT ROTTERDAM

Address

50,Dr. Molewaterplein 50 Erasmus University Hospital
3015 Ge Rotterdam

Netherlands

Administrative Contact

José VAN EIJNDHOVEN (Dr)

Participants (5)

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INSTITUT PASTEUR

France

PAUL-EHRLICH-INSTITUT, FEDERAL AGENCY FOR SERA AND VACCINES

Germany

RETROSCREEN LTD

United Kingdom

SOLVAY PHARMACEUTICAL BV

Netherlands

University of Cambridge

United Kingdom

Project information

Grant agreement ID: QLK2-CT-2002-01034

  • Start date

    1 October 2002

  • End date

    30 September 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 090 177

  • EU contribution

    € 1 675 516

Coordinated by:

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands