Objective It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariasocial sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologyimmunisation Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator STATENS SERUM INSTITUT EU contribution No data Address 5,ARTILLERIVEJ 5 2300 KOEPENHAGEN Denmark See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all LABORATORIO NACIONAL DE SAUDE PUBLICO Guinea-Bissau EU contribution No data Address Ministerio de Saude Publica BISSAU See on map Total cost No data LEIDEN UNIVERSITY Netherlands EU contribution No data Address Albinusdreef 2 2300 RC LEIDEN See on map Total cost No data MEDICAL RESEARCH COUNCIL The Gambia EU contribution No data Address Faraja BANJUL See on map Total cost No data PROJECTO DE SAUDE DE BANDIM Guinea-Bissau EU contribution No data Address BISSAU See on map Total cost No data
