Cel We plan to obtain biological tools (monoclonal, polyclonal antibodies and riboprobes) to examine in situ gene transcription and protein expression of a newly characterized cytokine: HILDA (Human Interleukin Da). This cytokine is produced by lymphocytes, monocytes/Macrophages and several tumor cell lines. Target cells are macrophages, embryonic stem cells, bone marrow progenitors and possibly endothelial cells. Antibodies will be prepared against HILDA and hydrophylic non-glycosylated HILDA peptides. Transcription and expression of HILDA - in comparison with other cytokines - will be studied in allotransplantation (rejection and tolerance) and in autoimmune disease (multiple sclerosis and auto-immune encephalitis) in humans and in rats. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineimmunologyautoimmune diseases Program(-y) FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992 Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania CSC - Cost-sharing contracts Koordynator UNIVERSIT DE NANTES Wkład UE Brak danych Adres Quai de Tourville 1 44035 NANTES Francja Zobacz na mapie Koszt całkowity Brak danych
