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Neuophysiological and Neurochemical Characterization of convulsive, nonconvulsive and mixed epilepsies in genetic animal models: possible role of histaminergic/dopaminergic interaction in the brain

Project information

Grant agreement ID: INTAS-2001-00690

  • Start date

    1 June 2002

  • End date

    31 May 2004

Funded under:

IC-INTAS

Coordinated by:

University of Kuopio

Finland

Objective

Neurochemical, behavioural and electroencephalographical correlates of seizure activity (of convulsive and non-convulsive types) will be studied in KM, Wistar and WAG/Rij rat strains, while modifying the brain histaminergic, dopaminergic, and GABAergic systems. The modulation of three receptor systems is an opportunity to develop functional (physiological, anatomical) models for the interaction between these receptor systems. The resulted experimental data will form a basis for systemic, multi-approached analysis, intended to yield fundamental new knowledge on the basic brain mechanisms, as well as new targets for pharmaceutical approaches. Comparison of convulsive, non-convulsive and mixed animal models of epilepsies permits the identification of the critical features from a variety of observed parameters. The specially designed software will evaluate the non-stationary character of epileptic dynamic and most of the pharmacological effects. Additionally, three-component mathematical model of ensembles of neuron-like elements will be used to simulate the neurophysiological experiments.

The proposed project involves 5 teams (2 INTAS member teams, and 3 NIS teams), which are actively working in the fields of pharmacology (Department of Pharmacology and Toxicology of University of Kuopio, Finland; Nijmegen Institute for Cognition and Information, Catholic University of Nijmegen, the Netherlands; Institute of Pharmacology of Russian Academy of Medical Sciences, Russian Federation), neurophysiology and electrophysiology (Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russian Federation; Nijmegen Institute for Cognition and Information, Catholic University of Nijmegen, the Netherlands) and computer sciences and neuronal networks (Institute of Applied Physics of Russian Academy of Sciences, Nijni Novgorod, Russian Federation). Some of the participating teams have significant experience of collaboration other ones have just started with joint research or exchange of ideas. This should result in quick start with the planned experiments and mutual interest of the participating teams in multi-faceted approach.

In summary, it is hoped that the proposed project will revile actual disturbances in these neurotransmitter system in the living brain. We do realise that the development of such physiological models will neither be easy nor straight forward, however, the potential benefit of such physiological models will be invaluable for providing an insight into how the brain actually functions.

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Coordinator

University of Kuopio

Address

Harjulantie 1
70211 Kuopio

Finland

Participants (4)

Academy of Medical Sciences

Russia

Catholic University of Nijmegen

Netherlands

Russian Academy of Sciences

Russia

Russian Academy of Sciences

Russia

Project information

Grant agreement ID: INTAS-2001-00690

  • Start date

    1 June 2002

  • End date

    31 May 2004

Funded under:

IC-INTAS

Coordinated by:

University of Kuopio

Finland