Objetivo This project deals with the exploration of functionalised boron cage compounds for use in radiodiagnostics and radiotherapy. Various derivatives of such compounds are here proposed as in vivo carriers of radionuclides. Especially compounds with stable bonds between the radionuclide and the boron cage, and with functional groups, which allow conjugation to biomolecules, will be studied.Together the 7 teams involved will specifically explore the following three tasks:1.The use of closo-dodecaborate anion [B12H12]2- as linker for radiohalogenation of macromolecules. Different functional derivatives of the closo-dodecaborate anion will be synthesized and their halogenation with various radiohalogens (bromine, iodine, astatine) will be studied;2.Radioimmunoconjugates with proteins, antibodies, shorter peptides containing radiohalogen-bearing closo-dodecaborate cage will be prepared using indirect and direct approaches. The selection of radiohalogen label will be made in accordance with the objectives of individual biochemical experiments and the "time window" required;3. Metallacarborane complexes of different types will be used as carriers of various radioactive metal isotopes. The complexes which will be prepared include the dicarbaundecaborate complexes of cobalt, iron, nickel, and copper containing functional groups for conjugation with macromolecules, tris(2-mercapto-1,2-carboran-1-ylmethyl)amine gallium, and copper(I) bis(1,2-carboranyl diphosphine) complexes. Radioconjugates of the functional derivatives of metallabis (dicarbollides) with macromolecules will be prepared. Stability and immunoreactivity of the radioimmunoconjugates prepared will be studied. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) 3 - Chemistry OPEN - OPEN Call Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador Uppsala University Aportación de la UE Sin datos Dirección Thunbergsvagen 5A, Box 531 752 31 Uppsala Suecia Ver en el mapa Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Belarus National Academy of Sciences Bielorrusia Aportación de la UE Sin datos Dirección 13 Surganov Str. 220072 Minsk Ver en el mapa Coste total Sin datos Free University of Brussels Bélgica Aportación de la UE Sin datos Dirección Pleinlaan 2 1050 Brussels Ver en el mapa Coste total Sin datos M.V. Lomonosov Moscow State University Rusia Aportación de la UE Sin datos Dirección Leninskie Gory 119899 Moscow Ver en el mapa Coste total Sin datos Russian Academy of Sciences Rusia Aportación de la UE Sin datos Dirección 28 Vavilov Street 117813 Moscow Ver en el mapa Coste total Sin datos Spanish Council for Scientific Research España Aportación de la UE Sin datos Dirección Campus de la UAB 08193 Bellaterra Ver en el mapa Coste total Sin datos State Scientific Center of the Russian Federation Rusia Aportación de la UE Sin datos Dirección 25 Bolshaya Cheremushkinskaya Street 117259 Moscow Ver en el mapa Coste total Sin datos
