Objectif The main objective of this project is to compare distantly related animals with the aim to determine to what extent the behavioural functions of serotonin (5-hydroxytryptamine, 5-HT), as well as those of the endogenous opioid system, are conserved in evolution, and whether the two systems operate synergistically. With this aim, it is planned(1) to study the effects of serotonergic and opioidergic drugs on motor behaviours of experimental animals representing various major taxons, and to reveal both similarities and differences;(2) in selected animals, to investigate the central neuronal mechanisms underlying the observed serotonin- and opioid-regulated behaviours and, as far as possible, to describe them in terms of identified neurons and neuronal networks. The proposers are experienced in neuroethology and behavioral pharmacology of well investigated, the so called "model" animals: mice (the Novosibirsk team), fish carassius auratus (the Borok Team), cricket Gryllus bimaculatus (the Goettingen team), caddis fly larve Chaetopterix villosa (the Borok team), gastropod molluscs Lymnaea stagnalis and Helix pomatia (the Kaliningrad and Moscow team) and leech Hirudo medicinalis (The Portsmouth team). In this project, the efforts of these participants will be combined, using both similar and complementary methodological approaches (behavioural pharmacology, electrophysiology, immunocytochemistry and radioligand methods). Collaborative experiments between teams are also planned.The main activities of this project are:Mice: (1) Study of the effects of different 5-HTergic and peptidergic drugs on aggressive and submissive behaviours;(2) Study of the agression-related changes in the 5-HT1A, 5-HT2A, mu and kappa opioid receptor binding sites in the brain;Carassius auratus:(1) Study of the effects of serotonergic and opioidergic drugs on motor behaviors in the goldfish, with special reference to the exploratory behaviour;(2) Examination of a possible correlation between above drug-induced changes in behavior and ATPase activity of the nervous tissue;Gryllus bimaculatus: Study of the involvement of serotonin and opioid-like peptides in social, escape and locomotor behaviorsChaetopterix villosa (F.): Study of the effects of serotonergic and opioidergic drugs on motor behaviours, with special reference to the exploratory behaviour ;Lymnaea stagnalis and Helix pomatia:(1) Study of the effects of serotonergic and opioidergic drugs on the feeding, defensive and locomotor behaviour;(2) Analysis of the effects at the cellular level;(3) Study of the effects of methabolic precursor of 5HT on isolated 5HT-ergic neurons.Hirudo medicinalis:(1) Study of the distribution of opioid-like immunoreactive neuropeptides other than met-enkephalin;(2) Study of the behavioural effects of serotonergic and opioidergic drugs. Programme(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Thème(s) 4 - Life Sciences RUSSIA - RUSSIA Appel à propositions Data not available Régime de financement Data not available Coordinateur Universitat Gottingen Contribution de l’UE Aucune donnée Adresse Berliner Str. 28 37073 Gottingen Allemagne Voir sur la carte Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse 152742 Borok, Yaroslavskaya obl. Voir sur la carte Coût total Aucune donnée Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse Vavilova Str.26 117808 Moscow Voir sur la carte Coût total Aucune donnée Siberian branch of Russian Academy of Sciences Russie Contribution de l’UE Aucune donnée Adresse Lavrentiev prospect, 10 630090 Novosibirsk Voir sur la carte Coût total Aucune donnée University of Kaliningrad Russie Contribution de l’UE Aucune donnée Adresse Universitetskaya 2 236040 Kaliningrad Voir sur la carte Coût total Aucune donnée University of Portsmouth Royaume-Uni Contribution de l’UE Aucune donnée Adresse King Henry I Street P01 2DY Portsmouth Voir sur la carte Coût total Aucune donnée