Objective This project addresses the question of interactions between PAHs in the urban ambient air mixture and how they may affect the hypothesis of risk additivity which underlies current risk assessment methodologies for PAH mixtures. Studies in vitro (using rodent and human tissues) and in vivo (rodents) are proposed to examine qualitatively and quantitatively parameters related to the tumour initiating and promoting potency of selected PAHs, acting alone or in mixtures, and to test the hypothesis of risk additivity. The parameters to be examined include, among others, macromolecular binding, in vitro and in vivo mutagenesis, changes in gene expression, receptor binding, and others, as well as initiating and promoting potencies in the 2-stage mouse skin test. The outcome of the project may aid in the definition of improved air quality standards and monitoring strategies. Fields of science natural scienceschemical sciencesorganic chemistryhydrocarbonsengineering and technologyenvironmental engineeringair pollution engineeringmedical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-4. - Key action Environment and Health Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator NATIONAL HELLENIC RESEARCH FOUNDATION EU contribution No data Address 48,Vas. Constantinou Avenue 48 11635 ATHENS Greece See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all STOCKHOLM UNIVERSITET Sweden EU contribution No data Address Svante Arrhenius vaeg, 12 106 91 STOCKHOLM See on map Total cost No data UNIVERSITY OF LEICESTER United Kingdom EU contribution No data Address University Road LE1 7RH LEICESTER See on map Links Website Opens in new window Total cost No data UNIVERSITY OF MAASTRICHT Netherlands EU contribution No data Address Universiteitssingel, 40 6229 ER MAASTRICHT See on map Total cost No data UNIVERSITY OF SURREY United Kingdom EU contribution No data Address GUILDFORD See on map Links Website Opens in new window Total cost No data
