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Quality of skin as a barrier to ultra-fine particles

Ziel

Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows.

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Koordinator

UNIVERSITAET LEIPZIG

Adresse

Linnestrasse 5
04103 Leipzig

Deutschland

Kontakt Verwaltung

Peter GUTJAHR-LOESER (Mr)

Beteiligte (6)

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Alles aufklappen

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Frankreich

INSTITUTO TECNOLOGICO E NUCLEAR

Portugal

JAGIELLONIAN UNIVERSITY

Polen

THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS

Polen

UNIVERSITE DE BORDEAUX I

Frankreich

UNIVERSITY OF DEBRECEN

Ungarn

Projektinformationen

ID Finanzhilfevereinbarung: QLK4-CT-2002-02678

  • Startdatum

    1 Januar 2003

  • Enddatum

    30 Juni 2006

Finanziert unter:

FP5-LIFE QUALITY

  • Gesamtbudget:

    € 1 396 888

  • EU-Beitrag

    € 1 097 994

Koordiniert durch:

UNIVERSITAET LEIPZIG

Deutschland

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