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Quality of skin as a barrier to ultra-fine particles

Objective

Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows.

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Coordinator

UNIVERSITAET LEIPZIG

Address

Linnestrasse 5
04103 Leipzig

Germany

Administrative Contact

Peter GUTJAHR-LOESER (Mr)

Participants (6)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

INSTITUTO TECNOLOGICO E NUCLEAR

Portugal

JAGIELLONIAN UNIVERSITY

Poland

THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS

Poland

UNIVERSITE DE BORDEAUX I

France

UNIVERSITY OF DEBRECEN

Hungary

Project information

Grant agreement ID: QLK4-CT-2002-02678

  • Start date

    1 January 2003

  • End date

    30 June 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 396 888

  • EU contribution

    € 1 097 994

Coordinated by:

UNIVERSITAET LEIPZIG

Germany

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