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Interplay among mitochondria and p53 family proteins during apoptosis induced by dna damage - a new strategy for cancer therapy

Objective

DNA damaging agents (radiation and chemotherapeutic drugs) play a major role in the treatment of cancer. In tumours displaying high treatment sensitivity, these agents activate apoptotic pathways while resistant tumours show a blockade of these pathways. This project focuses on the analysis of the interplay between mitochondria and the p53 family proteins, sensors of DNA damage, in order to identify and verify new molecular targets responsible for therapy resistance of tumour cells. The main long-term goal of this proposal is to elucidate the mechanisms accounting for tumour resistance to killing, in order to allow the development of new strategies for cancer therapy. Research groups involved in this proposal have long track records in apoptosis research and are now joining efforts with a clinical partner engaged in exploring apoptotic mechanisms of treatment resistance in lung cancer. In addition, an industrial partner will join the project to provide genomic and bioinorganic capabilities and a route to commercial exploitation.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KAROLINSKA INSTITUTE
Address
Nobels Vaeg, 13
171 77 Stockholm
Sweden

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Institut Gustave Roussy, Pavillon De Recherche 1,
94805 Villejuif
EIRX THERAPEUTICS LTD
Ireland
Address
Cork Airport Business Park 2800, Kinsale Road
Cork
INSTITUT GUSTAVE ROUSSY
France
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
Via Orazio Raimondo 18
Roma
UNIVERSITE DE PARIS-SUD XI
France
Address
Rue Georges Clemenceau 15
91405 Orsay
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street 2
P.O.Box 26 Rehovot