CORDIS
EU research results

CORDIS

English EN
Demonstration of increased yield and productivity in selected commercial organisms by strategic transformation of key genes from aspergillus niger

Demonstration of increased yield and productivity in selected commercial organisms by strategic transformation of key genes from aspergillus niger

Objective

This programme will demonstrate that the transfer of specific genes from an Aspergillums Niger strain, which produces citric acid with close to theoretical efficiency, into other commercial micro-organisms will enhance the pool of precursors in those organisms and lead to increased yield and production rates for their end products. The two key enzymes, pike and axle, lead to increased glycol tic flux and the uncoupling of respiration from ATP production respectively, which, together with high glucose levels, will lead to increased metabolic fluxes and steady state levels of intermediates. Such a demonstration of high yield and productivity will then be transferred directly to the production strains of European manufacturers.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

NATIONAL INSTITUTE OF CHEMISTRY

Address

19,Hajdrihova 19
1150 Ljubljana

Slovenia

Administrative Contact

Peter VENTURINI (Dr.)

Participants (5)

Sort alphabetically

Expand all

ARISTOTLE UNIVERSITY OF THESSALONIKI

Greece

BEOCARTA LTD

United Kingdom

GRAZ, UNIVERSITY OF TECHNOLOGY

Austria

LEK, PHARMACEUTICAL AND CHEMICAL COMPANY D.D.

Slovenia

UNIVERSITY OF STRATHCLYDE

United Kingdom

Project information

Grant agreement ID: QLK3-CT-2002-02038

  • Start date

    1 November 2002

  • End date

    31 October 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 788 901

  • EU contribution

    € 1 122 356

Coordinated by:

NATIONAL INSTITUTE OF CHEMISTRY

Slovenia