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Glucocorticoid hormone programming in early life and its impact on adult health

Objective

Low birth weight in humans is associated with increased risk of hypertension, diabetes or affective disorders in later life. Excessive foetal exposure to glucocorticoids (GCs) retards organism growth, as GCs exert prenatal programming in a variety of target tissues. Whilst many researchers have argued on the basis of conventional animal models to explain the links between prenatal GC exposure and the commonest human disorders, none has shown strict relevance to humans. To elucidate the mechanisms in a primate model, we propose extending the studies in rats to marmoset monkeys. The animals will be treated prenatally with GCs, studying the impact upon potential adverse metabolic programming, reproductive and immune function, HPA axis activity, brain function and morphology and behaviour. Understanding how such prenatal programming works provides prospects for disease prevention and health promotion.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

DEUTSCHES PRIMATENZENTRUM GMBH
Address
4,Kellnerweg 4
37077 Goettingen
Germany

Participants (6)

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN
Germany
Address
Robert-koch-strasse 40
37075 Goettingen
FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
151,Lange Kleiweg 139
2288 GJ Rijswijk Zh
KAROLINSKA INSTITUTE
Sweden
Address
Karolinska Hospital
171 76 Stockholm
LEIDEN UNIVERSITY
Netherlands
Address
55,Einsteinweg 55 Gorlaeus Laboratories
2333 CC Leiden
SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZUERICH
Switzerland
Address
Schloerenstrasse 16
8603 Schwerzenbach
UNIVERSITY OF EDINBURGH
United Kingdom
Address
Chalmers Street 37
EH3 9ET Edinburgh