CORDIS
EU research results

CORDIS

English EN

Development of a malaria resistance DNA chip as public health tool for the management of plasmodium falciparum malaria drug resistance

Project information

Grant agreement ID: QLK2-CT-2002-01503

  • Start date

    1 January 2003

  • End date

    30 June 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 873 664

  • EU contribution

    € 1 300 472

Coordinated by:

UNIVERSIDADE NOVA DE LISBOA

Portugal

Objective

Genetic diversity of malaria parasites is a major obstacle to develop rational control strategies against this poverty related disease. Increase of health threatening drug resistance must be monitored and prevented to protect introduced drugs. We propose to evaluate newly developed DNA micro arrays for drug resistance monitoring in affected areas. Results will allow to capture dynamics of drug resistance and to forecast its development by establishing a community based Genetic Resistance Index, providing tools for rational and evidence based decisions on optimal use of drugs. We will assess the relationship between in vivo drug sensitivity and in vitro susceptibility to several anti-malarial and prevalence of multiple Snips providing correlates for clinical resistance. Sequencing will identify additional informative cordons. We will also explore putt as a potential marker for resistance to artemisinin derivatives.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSIDADE NOVA DE LISBOA

Address

Rua De Junqueira 96
1349 Lisboa

Portugal

Participants (6)

INSTITUT PASTEUR

France

INSTITUT PASTEUR DE LA GUYANE FRANCAISE

France

INSTITUT PASTEUR DE MADAGASCAR

Madagascar

INSTITUT PASTEUR DU CAMBODGE

Cambodia

Institut Pasteur de Dakar

Senegal

SWISS TROPICAL INSTITUTE

Switzerland

Project information

Grant agreement ID: QLK2-CT-2002-01503

  • Start date

    1 January 2003

  • End date

    30 June 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 873 664

  • EU contribution

    € 1 300 472

Coordinated by:

UNIVERSIDADE NOVA DE LISBOA

Portugal