Skip to main content

Protein folding, misfolding aggregation and disease

Objective

In 1996 researchers in Oxford, Groningen, EMBL, Rome and Granada together established a TMR network to address fundamental aspects of protein folding. This proved highly successful and lead to several significant scientific advances. This application is to fund the expansion of the network into the 5th framework. The goals are :
i) to build on the achievements of the previous network;
ii) to continue the progress in understanding the mechanism of protein folding and iii) to exploit our collective expertise to tackle the developing question of protein misfolding and disease. Specifically, the aim of the new network is to understand how interactions between amino acid residues lead to the kinetic and thermodynamic control of protein folding in order to develop the ability to predict which peptide sequences will fold a unique structure, which will not, and which may form toxic high order aggregates such as amyloid fibrils.
Objectives include:
1. To understand in detail the mechanisms of the folding of several small proteins, with particular emphasis on the relationship between folding kinetics, folding mechanism and structure.
2. To explore the evolutionary basis of naturally occurring protein sequences in terms of their folding behavior, with emphasis on the importance of the avoidance of aggregation and fibril formation.
3. To structurally characterize folding intermediates and explore the relationship between folding intermediates and species involved in initiating aggregation in peptides or proteins. To achieve these objectives the network will use a coordinated approach combining biophysical , protein engineering and computational techniques that is the strength of the Folding Network.

Funding Scheme

NET - Research network contracts

Coordinator

UNIVERSITY OF GRONINGEN
Address
4,Nijenborgh 4
6747 AG Groningen
Netherlands

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Du Professeur Calmette 1
59019 Lille
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
69012 Heidelberg
UNIVERSIDAD DE GRANADA
Spain
Address
S/n,avenida Fuentenueva S/n
18071 Granada
UNIVERSITY OF FLORENCE
Italy
Address
Viale Morgagni 50
50134 Firenze
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
2,Piazzale Aldo Moro 5
00185 Roma
University of Cambridge
United Kingdom
Address
Lensfield Road
CB2 1EW Cambridge