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Protein folding, misfolding aggregation and disease

Protein folding, misfolding aggregation and disease

Objective

In 1996 researchers in Oxford, Groningen, EMBL, Rome and Granada together established a TMR network to address fundamental aspects of protein folding. This proved highly successful and lead to several significant scientific advances. This application is to fund the expansion of the network into the 5th framework. The goals are :
i) to build on the achievements of the previous network;
ii) to continue the progress in understanding the mechanism of protein folding and iii) to exploit our collective expertise to tackle the developing question of protein misfolding and disease. Specifically, the aim of the new network is to understand how interactions between amino acid residues lead to the kinetic and thermodynamic control of protein folding in order to develop the ability to predict which peptide sequences will fold a unique structure, which will not, and which may form toxic high order aggregates such as amyloid fibrils.
Objectives include:
1. To understand in detail the mechanisms of the folding of several small proteins, with particular emphasis on the relationship between folding kinetics, folding mechanism and structure.
2. To explore the evolutionary basis of naturally occurring protein sequences in terms of their folding behavior, with emphasis on the importance of the avoidance of aggregation and fibril formation.
3. To structurally characterize folding intermediates and explore the relationship between folding intermediates and species involved in initiating aggregation in peptides or proteins. To achieve these objectives the network will use a coordinated approach combining biophysical , protein engineering and computational techniques that is the strength of the Folding Network.

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Coordinator

UNIVERSITY OF GRONINGEN

Address

4,Nijenborgh 4
6747 Ag Groningen

Netherlands

Administrative Contact

Kuipers DR. SIMON

Participants (6)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

UNIVERSIDAD DE GRANADA

Spain

UNIVERSITY OF FLORENCE

Italy

UNIVERSITY OF ROME "LA SAPIENZA"

Italy

University of Cambridge

United Kingdom

Project information

Grant agreement ID: HPRN-CT-2002-00241

  • Start date

    1 October 2002

  • End date

    30 September 2006

Funded under:

FP5-HUMAN POTENTIAL

  • Overall budget:

    € 1 499 843

  • EU contribution

    € 1 499 843

Coordinated by:

UNIVERSITY OF GRONINGEN

Netherlands