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Novel surfaces for switchable nucleic acids adsorption/ desorption for analytical assays

Project information

Grant agreement ID: QLK3-CT-2002-02075

  • Start date

    1 January 2003

  • End date

    31 December 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 999 436

  • EU contribution

    € 957 343

Coordinated by:

NATIONAL RESEARCH COUNCIL OF ITALY

Italy

Objective

This proposal aims to provide platform technology for the rapid extraction and purification of genetic material (DNA and RNA) from any kind of sample (medical and environmental). End user applications cover all fields in which the analysis of genetic material is important, involving several key actions in various thematic programmes. The technology to be developed is based on novel organic dendrite functionalised surfaces switch able from an adsorbing state during the extraction phase to a desorbing state during the elution phase. The design of the dendrites is directed by rigorous chemical-chemical analysis of data on molecular-level interactions, mechanisms and relevant parameters obtained via in site evanescent wave monitoring of the functionalised surfaces during NA binding. Surfaces maximizing recovery rates will be incorporated in high-throughput automated instrumentation for NA recovery.

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Coordinator

NATIONAL RESEARCH COUNCIL OF ITALY

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Participants (4)

COLLEGIUM BASILEA (INSTITUTE OF ADVANCED STUDY)

Switzerland

MICROVACUUM LTD.

Hungary

ROCHE INSTRUMENT CENTER AG

Switzerland

UNIVERSITY OF BRIGHTON

United Kingdom

Project information

Grant agreement ID: QLK3-CT-2002-02075

  • Start date

    1 January 2003

  • End date

    31 December 2006

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 1 999 436

  • EU contribution

    € 957 343

Coordinated by:

NATIONAL RESEARCH COUNCIL OF ITALY

Italy