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Bse transmission through food and blood products: a study in primates to assess the risk for humans

Objective

Independent lines of evidence causatively link vCJD and BSE through consumption of contaminated meat products. Almost 200,000 cattle have died from BSE within the last 15 years; hundreds of thousands of humans must have been exposed. Over 100 vCJD cases have been verified, the yearly incidence of death is currently rising by 33%. An unknown number will follow, others may become inapparent carriers, a potential source of inter-human transmission. Risk assessment of the human population to contract vCJD is paramount. We will establish the infectious dose contained in contaminated food in a non-human primate species closely related to man and examine whether the orally induced monkey TSE is transmissible through transfusion of blood or its products. These quantitative values will allow to more precisely estimate the risk of BSE transmission to individuals and the overall human population through contaminated food as well as blood and blood products.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

DEUTSCHES PRIMATENZENTRUM GMBH
Address
4,Kellnerweg 4
37077 Göttingen
Germany

Participants (4)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
60-68,Route Du Panorama 18
92265 Fontenay Aux Roses
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
00161 Roma
PAUL-EHRLICH-INSTITUT, FEDERAL AGENCY FOR SERA AND VACCINES
Germany
Address
Paul-ehrlich-strasse 51-59
63225 Langen
SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL
Sweden
Address
Nobels Vaeg 18
Solna