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Antibiotic targeting of wolbachia endosymbiotic bacteria as a new approach to the treatment of filarial infection and disease

Project information

Grant agreement ID: ICA4-CT-2002-10051

  • Start date

    1 December 2002

  • End date

    1 December 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 1 405 000

  • EU contribution

    € 1 405 000

Coordinated by:

UNIVERSITY OF BONN MEDICAL CENTER

Germany

Objective

Wolbachia are symbiotic endobacteria in filarial nematodes that have recently emerged as targets for an improved chemotherapy of filariasis by tetracycline antibiotics, with the potential to close the gaps left open in current mass treatment programs. The purposes of this project are i) to obtain the optimal regimen with anti-Wolbachia antibiotics leading to Wolbachia depletion and sterilization or killing of adult worms in human filariasis (lymphatic filariasis, loiasis and onchocerciasis); ii) to analyse the role of Wolbachia in inflammatory processes which lead to disease manifestations (acute episodes of lymphangitis); iii) to investigate the role of Wolbachia release by microfilaricidal therapy in the induction of drug side effects. In their combination, the studies will allow to assess the role of Wolbachia in pathogenesis and as targets for the long-needed for sustained interruption of transmission.

Coordinator

UNIVERSITY OF BONN MEDICAL CENTER

Address

Sigmund-Freud-Strasse 25
53105 Bonn

Germany

Participants (6)

LEIDEN UNIVERSITY

Netherlands

LIVERPOOL SCHOOL OF TROPICAL MEDICINE

United Kingdom

RESEARCH FOUNDATION IN TROPICAL DISEASES AND ENVIRONMENT

Cameroon

TROPICAL MEDICAL RESEARCH STATION KUMBA

Cameroon

UNIVERSITY OF INDONESIA

Indonesia

UNIVERSITY OF SCIENCE AND TECHNOLOGY, KUMASI

Ghana

Project information

Grant agreement ID: ICA4-CT-2002-10051

  • Start date

    1 December 2002

  • End date

    1 December 2005

Funded under:

FP5-INCO 2

  • Overall budget:

    € 1 405 000

  • EU contribution

    € 1 405 000

Coordinated by:

UNIVERSITY OF BONN MEDICAL CENTER

Germany